Ares is malicious and brutal. Throughout his career, he has demonstrated his ruthlessness, even siding with Norman Osborn as part of the Dark Avengers.
Chthon represents the black magic that seeks out corrupted individuals. Artifacts such as the Darkhold are tied to Chthon's power, demonstrating the black heart at its core.
Cul Borson is also known as The Serpent, a god of ancient Asgardian legend. He is cold and calculating, indifferent to the many lives he has taken.
Her evil spirit may be swayed by her role, but she certainly goes above and beyond, demonstrating a level of joy in destruction.
God of symbiotes, it's hard to know how many lives he's taken, both because of his bond with symbiotes and because of his violent desires.
Associated with demons, hell and the underworld, there is a sense that Lilith embodies all of humanity's sins and scandals.